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Oxford team takes cancer fight to the next level

29 January 2010
A group of scientists from Oxford could have registered a significant breakthrough in the battle against cancer.

The team, from Oxford University, has examined how cancer stem cells affect the growth of tumours, with the latest results of a study published in the journal PNAS.

A better understanding of how these crucial cells operate could yield important progress in tackling cancer, as Dr Trevor Yeung of the Weatherall Institute of Molecular Medicine at Oxford University, explained.

"Cancer stem cells drive the growth of a tumour," he said. "If we could target treatments against these cells specifically, we should be able to eradicate the cancer completely."

While radiotherapy and chemotherapy are capable of combating dividing cells, Dr Yeung said there was evidence that cancer stem cells were more resistant and required a different approach in order to prevent the recurrence of cancer.

"It's like trying to weed the garden," he explained. "It's no good just chopping off the leaves, we need to target the roots to stop the weeds coming back."

Called cancer stem cells because they are capable of producing further cells like themselves - like stem cells present in normal body tissue - Dr Yeung suggested a more fitting term for them would be "cancer-driving cells" or "tumour-initiating cells".

Now the team plans to employ a new technique for obtaining samples rich in cancer stem cells, which could help catalyse cancer research.

Taken from bowel cancer cell lines, the sample can then be preserved in simple cell cultures in the laboratory, enabling the researchers to identify and study them in isolation.

Unlike previous processes - which required cancer biopsies from human patients that were then enriched - the new system is quicker and generates a reusable sample.

The potential for repeatable, high-throughput screening of potential drugs, as well as the ability to characterise cancer stem cells and their operation, could be the key to further development.

"In the long term, it should allow the development of more useful, safe and specific drugs targeting cancer stem cells," added Dr Yeung.

There are more than 200 different types of cancer, with an estimated 10.9 million people worldwide diagnosed with the disease each year. It is thought that almost 25 million people have received a diagnosis of cancer in the last five years. ADNFCR-1584-ID-19586966-ADNFCR

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