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Oxford brainwave helps develop new treatments

26 February 2010
Researchers at the Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) have co-authored a new paper which focuses on how images of the brain can be used to understand more about particular diseases.

Drawing on existing techniques which use magnetic resonance imaging (MRI) scans to reveal brain activity in particular circumstances or when performing certain tasks, the South-East-based experts have sought to establish a new means for examining brain activity.

Instead of asking volunteers to perform tasks and monitoring the resulting activity in the brain - known as functional MRI (fMRI) - the researchers have used "resting-state" fMRI.

In this method, people are simply required to lie under the scanner, with the researchers then using this resting state snapshot of the brain to compare against other subjects, removing some of the complications of identifying which elements are affecting the final image.

The scientists say this can help identify the characteristics behind a particular disease or condition.

Professor Steve Smith, Associate Director at FMRIB, explained: "If you're interested in a specific group of people or patients - say with Alzheimer's for example - you want to find any differences in brain activity that might be of interest, not just those involved in a specific task.

"With resting-state fMRI, you don't necessarily have to know what you're looking for."

The FMRIB team, which specialises in harnessing MRI for neuroscience research, recently won £8 million in backing from the Medical Research Council, Engineering and Physical Sciences Research Council, Wolfson Foundation and University of Oxford to purchase and install cutting-edge MRI systems.

Now they hope to exploit the potential of the technique and their new apparatus, with Dr Clare Mackay and Professor Smith already identifying differences in young people's brain activity which were linked to an increased risk of Alzheimer's as a result of a gene variant.

That test was hailed by Dr Mackay as having the potential to lead towards a "tantalising prospect" - the ability to help distinguish who will go on to develop Alzheimer's.

The resting state fMRI is also being touted as a potential indicator for other differences in brain activity, helping to characterise factors like age, behaviour or disease progression.

Oxford's academic expertise has helped establish the South East region as a leader in medical technology, with the life sciences sector flourishing thanks to an array of highly skilled operators and a sophisticated industrial infrastructure.

Oxford University, for example, works with a wide range of companies which harness the knowledge capital within the institution.

Isis Innovation, the university's wholly-owned technology transfer company, files an average of one new patent per week and the total value of spin-out companies originating from the university is estimated at £2 billion.ADNFCR-1584-ID-19639766-ADNFCR

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